- 1. 1.To be high on stimulants like Meth or coke. 2.To work obsessively or compulsively on something. 3.To adjust something. 4.To be way wrong about something > 1.He did 4 fat ass lines, hes tweakin hard > 2.I was tweakin on my room for like 4 hours > 3.I was just Tweakin the carb on my truck > 4.you think the Boston Celtics are the best team ever..man your tweakin. Source: ecdict
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tweakin'
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