- 1. Contraction of the greeting "What's up?" which is a contraction of "What is up?" If you're really pressed for time, greet someone with a "[sup]"?. In any case, the greeter is rhetorically asking you what is going on in your life. Roughly synonymous with hello but less hip. > Hipster1: Wussup? > Hipster2: [Nuttin]'. > Hipster1: [Word]. > Hipster2: [Word is bond]. Source: ecdict
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wussup
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